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What is Chloroquine 250mg?
Chloroquine 250mg is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Buy Chloroquine 250mg online

Occasionally it is used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. It is taken by mouth. It is also being used experimentally in COVID-19 as of 2020.

Chloroquine phosphate had been also proposed as a treatment for SARS-CoV with in vitro tests successfully inhibiting the virus.

Pack content: 10 x 10 Tablets.

Molar mass: 319.872 g/mol
CAS ID: 54-05-7
Formula: C18H26ClN3
Trade name: Aralen, others
Elimination half-life: 1–2 months
Metabolism: Liver

Chloroquine 250mg, an old malaria drug, may help treat novel coronavirus, doctors say.

What do malaria and COVID-19 have in common? On the surface, not much. But according to early research, an old malaria drug called chloroquine might also work for the new coronavirus.

Could a decades-old malaria drug work to treat COVID-19? Elon Musk seems to think so, recently tweeting that it “might be worth considering chloroquine” for COVID-19. Although data are spare, studies so far seem to back up the billionaire entrepreneur’s suggestion.

Chloroquine 250mg, or hydroxychloroquine, has been used to treat malaria since 1944. It can be given before exposure to malaria to prevent infection, and it can also be given as treatment afterward. Buy Chloroquine 250mg online

Malaria is a disease that is caused by a parasite, unlike COVID-19. Nevertheless, laboratory studies show chloroquine is effective at preventing as well as treating the virus that causes severe acute respiratory syndrome, or SARS, a close cousin of COVID-19. Buy Chloroquine 250mg online

An effective treatment for #Coronavirus #COVID-19 has been found in a common anti-malarial drug – Chloroquine 250mg.buy chloroquine online usa

An Effective Treatment for Coronavirus (COVID-19) is Chloroquine phosphate.

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(1)
Chloroquine Phosphate
Imprint: 0115 2790
Strength: 250 mg
Color: White
Size: 10.00 mm
Shape: Round
Drug Class: Amebicides Antimalarial quinolines
Labeler / Supplier: Global Pharmaceuticals

(2)
Chloroquine Phosphate
Imprint: RF 27
Strength: 250 mg
Color: White
Shape: Round
Drug Class: Amebicides Antimalarial quinolines
Labeler / Supplier: Ranbaxy Pharmaceuticals Inc.

(3)
Chloroquine Phosphate
Imprint: 7010
Strength: 500 mg
Color: White
Size: 13.00 mm
Shape: Round
Drug Class: Amebicides Antimalarial quinolines
Labeler / Supplier: Global Pharmaceuticals

(4)
Chloroquine Phosphate
Imprint: WW 125
Strength: 500 mg
Color: Pink
Size: 13.00 mm
Shape: Round
Drug Class: Amebicides Antimalarial quinolines
Labeler / Supplier: West-Ward Pharmaceutical Corporation

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Uses:
Chloroquine is used to prevent or treat malaria caused by mosquito bites. Chloroquine belongs to a class of drugs known as antimalarials. Chloroquine 250mg

Chloroquine phosphate is used to prevent and treat malaria. It is also used to treat amebiasis. Chloroquine phosphate is in a class of drugs called antimalarials and amebicides.

This medication is typically used for the prevention of malaria. It may also have other uses. Chloroquine 250mg

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Treatment:
Indicated for acute attacks of malaria due to P. vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum. Chloroquine 250mg

Acute attack:
1 g (600-mg base) PO, THEN
500 mg (300 mg-base) PO after 6-8 hr THEN
500 mg (300 mg-base) PO at 24 hr and 48 hr after initial dose
Total dose of 2500 mg (1500 mg-base) in 3 days

Amebiasis, Extraintestinal:
1 g (600 mg base) PO qDay for 2 days, THEN

500 mg (300 mg base) qDay for 14-21 days

Dosage Modifications:
Hepatic impairment
Chloroquine phosphate tablets may concentrate in the liver; use with caution in patients with hepatic disease or alcoholism or in conjunction with known hepatotoxic drugs

Dosing Considerations:
Limitations of use
Do not use for the treatment of complicated malaria (high-grade parasitemia and/or complications [eg, cerebral malaria, acute renal failure])

Do not use for malaria prophylaxis in areas where chloroquine resistance occurs

Concomitant use with an 8-aminoquinoline drug is necessary for treatment of hypnozoite liver stage forms of P.vivax and P.ovale. Chloroquine 250mg

CLINICAL PHARMACOLOGY:
Chloroquine is rapidly and almost completely absorbed from the gastrointestinal tract, and only asmall proportion of the administered dose is found in the stools.

Approximately 55% of the drug inthe plasma is bound to nondiffusible plasma constituents. Excretion of chloroquine is quite slow,but is increased by acidification of the urine. Chloroquine is deposited in the tissues in considerableamounts. Chloroquine 250mg

In animals, from 200 to 700 times the plasma concentration may be found in the liver,spleen, kidney, and lung; leukocytes also concentrate the drug. The brain and spinal cord, incontrast, contain only 10 to 30 times the amount present in plasma.

Chloroquine undergoes appreciable degradation in the body. The main metabolite isdesethylchloroquine, which accounts for one fourth of the total material appearing in the urine;bisdesethylchloroquine, a carboxylic acid derivative, and other metabolic products as yetuncharacterized are found in small amounts. Slightly more than half of the urinary drug productscan be accounted for as unchanged chloroquine. Chloroquine 250mg

Microbiology:
Mechanism of Action: Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent.

The precise mechanism by which chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA. Chloroquine 250mg

Activity in Vitro and in Clinical Infections: Chloroquine is active against the erythrocytic forms of susceptible strains of Plasmodium falciparum, Plasmodium malariae, Plasmodium ovale, and Plasmodiumvivax.

Chloroquine is not active against the gametocytes and the exoerythrocytic forms including the hypnozoite stage (P. vivax and P. ovale) of the Plasmodium parasites.

In vitro studies with Chloroquine demonstrated that it is active against the trophozoites of Entamoeba histolytica. Chloroquine 250mg.

Drug Resistance:
Resistance of Plasmodium parasites to chloroquine is widespread (see INDICATIONS AND USAGE, Limitations of Use in Malaria and WARNINGS).

Plasmodium parasites exhibiting reduced susceptibility to hydroxychloroquine also show reduced susceptibility to chloroquine.

Patients in whom chloroquine or hydroxychloroquine have failed to prevent or cure clinical malaria or parasitemia, or patients who acquired malaria in a geographic area where chloroquine resistance is known to occur should be treated with another form of antimalarial therapy (see WARNINGS and INDICATIONS AND USAGE, Limitations of Use). Chloroquine 250mg

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